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Bioorganic Studies on Rhodopsins
Author(s) -
Nakanishi Koji,
Berova Nina,
Fishkin Nathan,
Fujioka Naoko
Publication year - 2002
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200200070
Subject(s) - rhodopsin , chemistry , opsin , chromophore , visual phototransduction , visual pigments , transduction (biophysics) , retinal , bioorganic chemistry , biophysics , g protein coupled receptor , fish <actinopterygii> , biochemistry , signal transduction , stereochemistry , photochemistry , biology , enzyme , fishery
Abstract A summary of ongoing bioorganic studies on rhodopsin, the most intensively studied G‐protein coupled receptor (GPCR) is given. The article includes: (i) general descriptions of rhodopsin and (ii) various naturally occurring retinal chromophores in animals, fish and microorganisms; (iii) the rationale for 6‐ s ‐ cis ‐11‐sicis retinal being the common chromophoric structure in visual pigments; (iv) electrostatic charge distribution within the opsin binding site; (v) the visual transduction cycle; and (vi) the changes occurring in the chromophore/receptor interactions allong the visual transduction path.