Antimicrobial Activity of Some Novel Thiourea, Hydrazine, Fused Pyrimidine and 2‐(4‐Substituted)anilinobenzoazole Derivatives Containing Sulfonamido Moieties | Zendy

ElGaby Mohamed S. A. | Zendy; Micky Jehane A. | Zendy; Taha Nadia M. | Zendy; Sh. ElSharief Marwa A. M. | Zendy

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Antimicrobial Activity of Some Novel Thiourea, Hydrazine, Fused Pyrimidine and 2‐(4‐Substituted)anilinobenzoazole Derivatives Containing Sulfonamido Moieties

Author(s) -

ElGaby Mohamed S. A.,

Micky Jehane A.,

Taha Nadia M.,

Sh. ElSharief Marwa A. M.

Publication year - 2002

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.200200064

Subject(s) - chemistry , thiourea , anthranilic acid , antimicrobial , pyrimidine , carboxylic acid , thiophene , hydrazine (antidepressant) , medicinal chemistry , molecule , organic chemistry , stereochemistry , chromatography

Thiophosgenation of sulfonamides 1a‐c in the presence of dilute HCl at room temperature furnished the isothiocyanatosulfonamides 2a‐c and treatment with aromatic amines gave 1,3‐disubstituted thioureas 3a,b . Also, interaction of two molecules of 2c with 1,4‐phenylenediamine yielded the novel bisthiourea 4 . Cyclocondensation of 2 with ortho amino carboxylic acid compounds such as anthranilic acids 8 , 5‐amino‐1‐phenyl‐pyrazol‐4‐carboxylic acid 9 and 4,5,6,7‐tetrahydro‐2‐amino‐benzo[b]thiophene‐3‐carboxylic acid 10 furnished the fused thiopyrimidines 11a‐d, 12 and 13 , respectively. 2‐Anilinobenzoazole derivatives 15a‐c, 16a, b and 17a,b were obtained through cyclocondensation of 2 with 1,2‐dinucleophiles.

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