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A Synthesis of Thalidomide
Author(s) -
Chang MengYang,
Chang ChungHo,
Chen ShuiTein,
Chang NeinChen
Publication year - 2002
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200200060
Subject(s) - thalidomide , chemistry , cycloaddition , yield (engineering) , total synthesis , stereochemistry , combinatorial chemistry , organic chemistry , medicine , materials science , metallurgy , multiple myeloma , catalysis
A synthesis of racemic thalidomide ( 1 ) was described and the important formal [3+3] cycloaddition strategy was a keystep. The total yield of thalidomide ( 1 ) was 18% in five steps from known 3 .
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