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Synthesis and Antimicrobial Activity of Novel Furothienoquinoxalines, Pyranothienoquinoxalines and Pyrimidopyranothienoquinoxalines
Author(s) -
Moustafa Osama S.,
ElOssaily Yasser A.
Publication year - 2002
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200200018
Subject(s) - quinoxaline , chemistry , phenacyl bromide , ethyl chloroacetate , antifungal , antimicrobial , phenacyl , bromide , medicinal chemistry , organic chemistry , combinatorial chemistry , medicine , dermatology , hydrate
The reaction of ethyl‐3‐mercaptoquinoxaline‐2‐carboxylate with phenacyl bromide, ethyl chloroacetate, chloroacetonitrile or chloroacetone furnished the corresponding 3‐hydroxy thieno[2,3‐ b ]quinoxaline. 2‐Cyano‐3‐hydroxythieno[2,3‐ b ]quinoxaline and 2‐acetyl‐3‐hydroxythieno[2,3‐ b ]quinoxa line were employed as precursors in the synthesis of some novel furo[2′,3′:4,5]thieno[2,3‐ b ]quinoxaline, pyrano[2′,3′:4,5]thieno[2,3‐ b ]quinoxaline and other heterocyclic systems fused with thieno[2,3‐ b ]quinoxalines. The antibacterial and antifungal activities of some the synthesised compounds were studied.