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Exploration of an Efficient Method for Optical Resolution of Etodolac
Author(s) -
Chou ShanYen,
Tseng ChinLu,
Chang LienShange
Publication year - 2001
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200100037
Subject(s) - etodolac , chemistry , racemization , diastereomer , resolution (logic) , salt (chemistry) , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , artificial intelligence , computer science
The exploration of an efficient method for resolving etodolac using either L ‐cinchonidinium salt or chiral isopinocamphenol diastereomeric esters is described herein. Furthermore, racemization mechanism of chiral etodolac is rationalized in terms of an isotope labeling experiment.