Total Synthesis of Kaempferol and Methylated Kaempferol Derivatives

Kaempferol ( 1 ), a natural product from various plants, was synthesized in which the longest linear sequence is only seven steps in over all yields of 47% from commercially avail able 1,3,5‐trimethoxybenzene (10). The methylated kaempferols 2–5 were also pre pared by use of this concise synthetic methodology. The key transformations in this synthesis involved the I 2 oxidative‐promoting‐cyclization and DDO oxidative hydroxylation. Several strategies to achieve 1 are provided.