Premium
Total Synthesis of Kaempferol and Methylated Kaempferol Derivatives
Author(s) -
Lee YeanJang,
Wu TsaoDong
Publication year - 2001
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200100033
Subject(s) - chemistry , kaempferol , hydroxylation , natural product , total synthesis , organic chemistry , oxidative phosphorylation , stereochemistry , quercetin , biochemistry , antioxidant , enzyme
Kaempferol ( 1 ), a natural product from various plants, was synthesized in which the longest linear sequence is only seven steps in over all yields of 47% from commercially avail able 1,3,5‐trimethoxybenzene (10). The methylated kaempferols 2–5 were also pre pared by use of this concise synthetic methodology. The key transformations in this synthesis involved the I 2 oxidative‐promoting‐cyclization and DDO oxidative hydroxylation. Several strategies to achieve 1 are provided.