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Synthesis of Novel N‐Pyridylcantharidinimides by Using High Pressure
Author(s) -
Lin PenYuan,
Shi ShengJie,
Lin LunHuei,
Chen HsueFen,
Hsu FengLin
Publication year - 2001
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200100009
Subject(s) - chemistry , cantharidin , yield (engineering) , high pressure , aminopyridines , medicinal chemistry , organic chemistry , combinatorial chemistry , thermodynamics , physics
The recently described pressure reaction in the presence of trithylamine with subsequent thermal (200°C) cyclization provided 13N‐pyridylcantharidinimides 4a‐4m from aminopyridines and cantharidin in yields of 15–83%. 2‐Amino‐3,5‐dichloropyridine failed to yield 4n .