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Synthesis of N ‐(1‐oxyl‐2,2,5,5‐tetramethylpyrrolin‐3‐yl)‐ N ′‐(3‐aryl‐5‐mercapto‐1,2,4‐triazol‐4‐yl)ureas and N ‐(3‐aryl‐5‐mercapto‐1,2,4‐triazol‐4‐yl)‐(1‐oxyl‐2,2,5,5‐tetramethylpyrrolin‐3‐yl)acidamide
Author(s) -
Zhang Yan,
Sun XiaoWen,
Zhang ZiYi,
Wang Qin,
Wang ShuFang
Publication year - 2000
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200000174
Subject(s) - chemistry , aryl , isocyanate , mass spectrum , medicinal chemistry , stereochemistry , organic chemistry , alkyl , polyurethane , ion
Abstract Nine novel N ‐(1‐oxyl‐2,2,5,5‐tetramethylpyrrolin‐3‐yl)‐ N ′‐(3‐aryl‐5‐mercapto‐1,2,4‐triazol‐4‐yl)ureas 3a∼3i were synthesized by the reaction of 1‐oxyl‐2,2,5,5‐tetramethylpyrrolin‐3‐yl isocyanate 1 with 4‐amino‐3‐aryl‐5‐mercapto‐1,2,4‐triazoles 2a∼2i and their anti‐tumor activity was evaluated. The mass spectra of the compounds synthesized were discussed.