Structure Identification of Aporphine Alkaloids by On‐Line Coupling of HPLC‐NMR with Loop Storage | Zendy

Tseng LiHong | Zendy; Braumann Ulrich | Zendy; Godejohann Markus | Zendy; Lee ShoeiSheng | Zendy; Albert Klaus | Zendy

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Structure Identification of Aporphine Alkaloids by On‐Line Coupling of HPLC‐NMR with Loop Storage

Author(s) -

Tseng LiHong,

Braumann Ulrich,

Godejohann Markus,

Lee ShoeiSheng,

Albert Klaus

Publication year - 2000

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.200000168

Subject(s) - chemistry , high performance liquid chromatography , nuclear magnetic resonance spectroscopy , acetonitrile , elution , chromatography , analytical chemistry (journal) , gradient elution , coupling (piping) , resolution (logic) , proton nmr , nuclear magnetic resonance , stereochemistry , mechanical engineering , physics , artificial intelligence , computer science , engineering

The potential of coupling HPLC separation methodology to on‐line high resolution nuclear magnetic resonance (NMR) spectroscopy has been demonstrated with a mixture of nine aporphine alkaloids. A loop storage procedure after separation has facilitated the identification of closely eluted peaks (α = k 2 /k 1 = 1.01 and Δv = 0.37 min = 367 μL). These were collected off‐line and identified by a 1D 1 H NMR spectrum. For this purpose an automated procedure has been implemented which includes the use of shaped pulses, multiple solvents suppression and 13 C satellite suppression of acetonitrile.

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