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Femtosecond Two‐Dimensional Infrared Spectroscopy
Author(s) -
Hochstrasser Robin M.,
Asplund Matthew C.,
Hamm Peter,
Ge NienHui
Publication year - 2000
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200000112
Subject(s) - chemistry , femtosecond , infrared , spectroscopy , infrared spectroscopy , resolution (logic) , pulse (music) , molecule , two dimensional infrared spectroscopy , resonance (particle physics) , infrared spectroscopy correlation table , nuclear magnetic resonance , molecular physics , optics , atomic physics , laser , physics , organic chemistry , quantum mechanics , artificial intelligence , detector , computer science
Abstract The dynamics occurring amongst the structures of peptides and small proteins present significant questions that are not readily addressed by conventional methods. Multiple pulse infrared experiments provide a promising alternative. The time resolution is easily fast enough to intercept the structures on different parts of the free energy surfaces. This paper reviews how infrared spectroscopy can be optimized by stretching it into two dimensions thereby making it possible to separately examine and assign the cross peaks arising from the interaction of different amide oscillators in the molecule. A variety of approaches such as pump/probe, self‐heterodyned pump/probe, three pulse photon echo and spectrally resolved echoes are described which are analogous to magnetic resonance schemes.