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Analysis of Synthetic Drugs in Chinese Medicine by High Performance Liquid Chromatography/Mass Spectrometry with In‐Source Collision Induced Dissociation
Author(s) -
Song Yi,
Cheng HsingLing,
Her GuorRong,
Wen KuoChing
Publication year - 2000
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200000064
Subject(s) - chemistry , mass spectrometry , chromatography , collision induced dissociation , dissociation (chemistry) , electrospray ionization , high performance liquid chromatography , electrospray , ionization , direct electron ionization liquid chromatography–mass spectrometry interface , analytical chemistry (journal) , chemical ionization , tandem mass spectrometry , ion , organic chemistry
Sixteen chemical drugs, often found in adulterated Chinese medicine, were studied by high performance liquid chromatography/atmospheric ionization mass spectrometry. Under optimal conditions, three pairs of compounds were either coeluted or unresolved. The lack of chromatographic resolution and the lack of specificity in UV detection were overcome by a method based on high performance liquid chromatography/electrospray mass spectrometry. This method was capable of detecting the adulterants based on their retention times, molecular ions, and characteristic fragments resulting from in‐source collision induced dissociation.