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Microwave Accelerated Cycloaddition Reactions of Nitrile Oxides and Allylic Alcohols
Author(s) -
Lu TaJung,
Tzeng GwoMing
Publication year - 2000
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200000022
Subject(s) - cycloaddition , chemistry , nitrile , regioselectivity , microwave , allylic rearrangement , microwave irradiation , photochemistry , hydrogen , organic chemistry , catalysis , quantum mechanics , physics
The application of microwaves in promoting the cycloaddition reactions of allyl alcohols with nitrile oxides using a domestic microwave oven and a focused monomode microwave reactor have demonstrated that not only was the reaction time substantially reduced, but also the reaction yields were significantly improved over the conventional stirred reactions. Microwave irradiation alters the regioselectivity of the cycloaddition reaction which favors the non‐hydrogen‐bond directed cycloadduct, isoxazoline 4 .