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Alcalase‐catalyzed Synthesis of Novel 2,6‐Dimethoxyhydroquinone‐3‐mercaptoacetyl‐peptide Conjugates
Author(s) -
Chen WenFu,
Jong MingChu,
Chen ShuiTein,
Sheh Leung
Publication year - 1999
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199900017
Subject(s) - chemistry , dipeptide , tripeptide , conjugate , catalysis , nucleophile , amino acid , peptide , peptide synthesis , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , mathematical analysis , mathematics
Seven dipeptide and one tripeptide conjugates of the cytotoxic drug 2,6‐dimethoxyhydroquinone‐3‐mercaptoacetic acid (DMQ‐MA) conjugates were prepared successfully by an alcalase‐catalyzed reaction in alcohols, using DMQ‐MA‐X‐OMe as the acyl donor and H 2 N‐Y‐CONH 2 as the nucleophile (where X and Y are amino acids, and amino acid/dipeptides, respectively).