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Reaction of 4‐Aryl‐3‐thiosemicarbazides with Phenylisothiocyanate: A Facile Synthesis of Thiazole, Pyrazole and Pyrimidine Derivatives
Author(s) -
Wardakhan Wagnat W.,
Fleita Daisy H.,
Mohareb Rafat M.
Publication year - 1999
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199900013
Subject(s) - chemistry , phenacyl bromide , thiazole , aryl , pyrazole , bromide , pyrimidine , phenacyl , medicinal chemistry , organic chemistry , stereochemistry , alkyl
The reaction of 4‐aryl‐3‐thiosemicarbazides 1a‐d with phenylisothiocyanate gave the intermediate potasium salts 2a‐d . The latter afforded 3a‐d, 13a‐d and 19 upon the reaction with phenacyl bromide, monochloroacetic acid and ethyl bromocyanoacetate respectively.