Premium
Synthesis of New 2‐[(Substituted‐pyrazolin‐1‐yl)carbonyl]‐thieno[2,3‐ b ]pyridine Derivatives
Author(s) -
Ho YuhWen
Publication year - 1999
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199900012
Subject(s) - chemistry , pyridine , carbohydrazide , catalysis , medicinal chemistry , base (topology) , organic chemistry , mathematical analysis , mathematics
The reaction of 3‐amino‐4,6‐dimethyl‐2‐thieno[2,3‐ b ]pyridine carbohydrazide ( 1 ) with appropriate chalcones 2a‐2d in the presence of acid catalyst produced the corresponding 3‐amino‐2‐[(3,5‐disubstituted‐pyrazolin‐1‐yl)carbonyl]‐4,6‐dimethylthieno[2,3‐ b ]pyridines 3a‐3d . 3‐Amino‐2‐[(3‐substituted‐pyrazolin‐1‐yl)carbonyl]‐4,6‐dimethylthieno[2,3‐ b ]pyridines 7a, 7b were also obtained by the cyclization reaction of carbohydrazide 1 with Mannich base derivatives 6a, 6b under basic condition.