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Studies with Polyfunctionally Substituted Heterocycles: New Synthesis of Pyrido[5′, 4′:2,3][1,3,4]oxadiazolo[3,2‐a]pyridine; Pyridazine; 1,3,4‐Oxadiazote; and Pyrazolo[1,5‐a]Pyrimidine Derivatives
Author(s) -
Barsy Magda A.,
Elmaghraby Mohammed A.,
Ahmed Salwa M.
Publication year - 1998
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199800099
Subject(s) - pyridazine , chemistry , pyrimidine , pyrazole , pyridine , yield (engineering) , oxadiazole , ethanol , medicinal chemistry , solvent , organic chemistry , stereochemistry , materials science , metallurgy
Cyanoacetohydrazide 1a reacts with 2‐arylhydrazoketons 2a,b and 3a,b in refluxing ethanol to yield pyrido[5′,4′:2,3][1,3,4]oxadiazolo[3,2‐a]pyridine and pyridazine derivatives; in the absence of solvent pyrazolo[1,5‐a]pyrimidine derivatives were obtained. The reaction of 2a,b and 3a,b will) benzoylhydrazine afforded 1,3,4‐oxadiazole and pyrazole derivatives.