A General Procedure for Synthesis of  N  G ‐Alkyl, and  N  G ‐Aryl‐ L ‐Arginines as Potential Nitric Oxide Synthase inhibitors | Zendy

Chen BorCherng | Zendy; Shiu Shi | Zendy; Yang DingYah | Zendy

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A General Procedure for Synthesis of N G ‐Alkyl, and N G ‐Aryl‐ L ‐Arginines as Potential Nitric Oxide Synthase inhibitors

Author(s) -

Chen BorCherng,

Shiu Shi,

Yang DingYah

Publication year - 1998

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.199800083

Subject(s) - chemistry , aryl , yield (engineering) , alkyl , nitric oxide synthase , arginine , derivative (finance) , atp synthase , stereochemistry , nitric oxide , combinatorial chemistry , organic chemistry , biochemistry , enzyme , amino acid , materials science , economics , financial economics , metallurgy

A general procedure for the synthesis of N G ‐alkyl, and N G ‐aryl‐ L ‐arginines with relatively high overall yield is reported. The key step involved the coupling of protected L ‐ornithine 4 with isothiourea 7 to give the fully protected N G ‐aryl‐ L ‐arginine derivative 8 . Subsequent deprotection of 8 in acidic condition provided the final target compound 9 with an overall yield of more than 80%.

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