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First Total Synthesis of 1,2‐Dehydronephthenol
Author(s) -
Li Weidong,
Qu Jin,
Li Jing,
Li Ying,
Li Yulin
Publication year - 1997
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199700077
Subject(s) - chemistry , diterpene , aldehyde , total synthesis , intramolecular force , yield (engineering) , farnesol , stereochemistry , organic chemistry , materials science , metallurgy , catalysis
The first total synthesis of 1,2‐Dehydronephthenol (15‐hydroxy‐cembra‐1,3,7,11‐tetraene), a novel cembranoid diterpene, was accomplished starting from trans, trans ‐farnesol through seven steps in an overall yield of 17% by employing titanium‐induced intramolecular keto aldehyde reductive olefination‐coupling as the key macrocyclization step.
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