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Cuprate‐ catalyzed Three‐Component Couplings of Functionalized Organozinc Reagents
Author(s) -
Lipshutz Bruce H.,
Gross Tim,
Buzard Daniel J.,
Tirado Raymond
Publication year - 1997
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199700001
Subject(s) - chemistry , reagent , zinc , electrophile , component (thermodynamics) , catalysis , cuprate , conjugated system , medicinal chemistry , combinatorial chemistry , organic chemistry , polymer , doping , optoelectronics , physics , thermodynamics
Organozinc reagents FG‐(CH 2 ) n ZnX containing electrophilic centers (FG) upon conversion to their corresponding zincates (FG‐(CH 2 ) n ZnMe 2 Li) and in the presence of 5–8 mol % MeCu(CN)Li, undergo 1,4‐additions to cyclic conjugated enones. The intermediate zinc enolates can be trapped with aldehydes to afford products of three‐component couplings.