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Micellar Electrokinetic Chromatography of Cephalosporin Antibiotics
Author(s) -
Chen SuHwei,
Wu HsinLung,
Wu ShouMei,
Kou HwangShang,
Lin ShunJin
Publication year - 1996
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199600057
Subject(s) - chemistry , micellar electrokinetic chromatography , chromatography , cephradine , cefuroxime , cephalosporin , cephalosporin antibiotic , sodium dodecyl sulfate , pulmonary surfactant , cefoxitin , electrokinetic phenomena , antibiotics , capillary electrophoresis , bacteria , biochemistry , biology , genetics , staphylococcus aureus
A simple micellar electrokinetic chromatographic (MEKC) method is described for the simultaneous separation of twelve cephalosporin antibiotics. The separation was performed in a phosphate buffer (0.1 M, pH 6.6) with sodium dodecyl sulfate (SDS) (0.1 M) as an anionic surfactant. The complete separation of twelve cephalosporins was attained in 36 min. Application of the method to the quantitative analysis of cefuroxime, cephalexin, cephapirin and cephradine in pharmaceutical preparations was demonstrated.