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Metal Ion Dependent Binding and Nuclease Activity of Hexaazacyclophane
Author(s) -
Chang Tsu Hsin,
Ong Chi Wi,
Chou Yi Meen,
Chuang KuoShen,
Wang Wen Jwu
Publication year - 1996
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199600012
Subject(s) - chemistry , nuclease , dithiothreitol , metal , hydrogen peroxide , dna , ligand (biochemistry) , metal ions in aqueous solution , tautomer , ion , crystallography , stereochemistry , biochemistry , enzyme , organic chemistry , receptor
The HAPP‐Fe complex was more active than HAPP‐Cu complex in cleavage of DNA in the presence of dithiothreitol and hydrogen peroxide. In contrast, the HAPP‐Cu complex was found to bind more strongly with λ‐DNA, whereas the HAPP‐Fe binds weakly. It was shown that the metal ion complexed with HAPP ligand can influence the binding and cleaving activity due to the ability of the ligand to undergo geometrical tautomerization.