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A Practical Route to Chiral Phenylalanine via the Condensation of Keto Acids with Amides and Asymmetric Hydrogenation
Author(s) -
Chau TayYuan,
Tsui JianHou,
Lin ChiChing,
Chan A. S. C.
Publication year - 1995
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199500137
Subject(s) - chemistry , phenylpyruvic acid , condensation , asymmetric hydrogenation , phenylalanine , catalysis , organic chemistry , enantioselective synthesis , amino acid , biochemistry , physics , thermodynamics
The condensation of β‐phenylpyruvic acid with amides gave olefinic intermediates in good yields (75‐80%). The asymmetric catalytic hydrogenation of α‐acetamidocinnamic acid with high enantioselectivity is described.
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