Direct Measurement of Enantiomeric Excess of Synthetic Tert‐Leucine with a Chiral‐Ligand‐Exchange Chromatography | Zendy

Wang ShwuHuey | Zendy; Kao HsinYi | Zendy; Chen ShuiTein | Zendy; Wang KungTsung | Zendy

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Direct Measurement of Enantiomeric Excess of Synthetic Tert‐Leucine with a Chiral‐Ligand‐Exchange Chromatography

Author(s) -

Wang ShwuHuey,

Kao HsinYi,

Chen ShuiTein,

Wang KungTsung

Publication year - 1995

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.199500132

Subject(s) - chemistry , enantiomer , reagent , leucine , column chromatography , chromatography , enantiomeric excess , ligand (biochemistry) , chiral ligand , stereochemistry , organic chemistry , amino acid , catalysis , enantioselective synthesis , receptor , biochemistry

Racemic tert ‐leucine can be completely resolved by ligand exchange chromatography (LEC) using a Chiralpak WH column. The retention time of the tert ‐leucine was decreased by increasing concentration of Cu 2+ , or decreasing pH of the eluent whereas it was unaffected by varying the temperature of eluent. Optimal conditions for complete separation of the D.L‐ tert ‐leucine were found to be (Cu 2+ , 5.0 mM, pH 5.5, 25 °C). The enantiomeric excess of synthetic tert‐leucine, a chiral auxiliary reagent, was determined.

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