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Resolution of Ibuprofen Catalyzed with Free and Immobilized Lipases
Author(s) -
Tai DarFu,
Huang ChiYuan,
Chao YunnHsin,
Luo JihMei,
Lin YiTsong,
Wu ShihHsiung
Publication year - 1995
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199500108
Subject(s) - chemistry , ibuprofen , catalysis , resolution (logic) , chromatography , combinatorial chemistry , organic chemistry , pharmacology , medicine , artificial intelligence , computer science
Enzymatic hydrolyses of ibuprofen esters produced 99% optically pure S‐(+)‐ibuprofen. The ee values of two enantiomers of ibuprofen were determined on a HPLC equipped with a chiral column.