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α‐Carbonyl Radicals for Total Synthesis of Natural Products
Author(s) -
Sha ChinKang,
Jean TsongShin,
Yau NeiTung,
Huang ShihJung,
Chiou RueyTorn,
Young JennFenn,
Lih ShinHong,
Tseng WeiHong
Publication year - 1995
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199500086
Subject(s) - chemistry , vinylsilane , total synthesis , radical , intramolecular force , radical cyclization , bicyclic molecule , stereochemistry , organic chemistry , catalysis
Intramolecular cyclization of α‐carbonyl radicals to the trimethylsilylacetylenic side chain gives bicyclic vinylsilane ketones and enones. Application of this cyclization to total synthesis of (±)‐modhephene is described.