Premium
A Convenient Synthesis of Antihyperlipoproteinemic Agent Gemfibrozil
Author(s) -
Wang HuiPo,
Lee On,
Fan ChinTsai,
Lee LainTze
Publication year - 1995
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199500075
Subject(s) - chemistry , gemfibrozil , hydrogenolysis , lactone , cycloaddition , organic chemistry , combinatorial chemistry , catalysis , biochemistry , cholesterol
A new synthesis of antihyperlipoproteinemic agent 2,2‐dimethyl‐5‐(2,5‐dimethylphenoxy)pentanoic acid (gemfibrozil, 1) is developed via hydrogenolysis of a novel β‐lactone 6, prepared from [2+2] cycloaddition of 3‐(2,5‐dimethylphenoxy)propanal with dimethylketene. The mild conditions applied in this process are especially convenient for the preparation of gemfibrozil on an industrial scale of production.