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Antineoplastic Alkaloids From Chinese Medicinal Plants and Their Analogs
Author(s) -
Lee KuoHsiung,
Sun Li,
Wang HuiKang
Publication year - 1994
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199400050
Subject(s) - chemistry , tetrandrine , vinca , aporphine , camptothecin , alkaloid , traditional medicine , stereochemistry , palmatine , colchicine , pharmacology , organic chemistry , medicine
The Chinese medicinal plant‐derived antineoplastic alkaloids and their analogs are reviewed with emphasis on those discovered from the authors' laboratory. The active compounds include camptothecin, colchicine, ellipticine, harringtonine, Vinca alkaloids, indirubin, (‐)‐sophocarpine, lycobetaine, monocrotaline, d‐tetrandrine, indicine N ‐oxide, maytansine, aporphine type alkaloids, palmatine, murrapanine, emarginatine alkaloids, and the alkaloids from Securinega virosa . The compounds are discussed briefly with the recent advances concerning their antitumor activity, structure‐activity relationships and mechanisms of action.