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Formation of Triplexes of Diastereoisomers of 2′‐ O ‐Methyladenylyl‐3′,5′‐2′‐ O ‐Methyladenosine Ethylphosphotriesters and 2′‐ O ‐Methyladenylyl‐ 3′,5′‐2′‐ O ‐Methyladenosine Methyl Phosphonates with Polyuridylic Acid and Polythymidylic Acid: A Steric Effect
Author(s) -
Kan LouSing,
Koo William,
Yano Junichi
Publication year - 1993
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199300100
Subject(s) - chemistry , diastereomer , steric effects , n6 methyladenosine , stereochemistry , methylation , biochemistry , dna , methyltransferase
Abstract The triplex formation of diastereoisomers of 2′‐ O ‐methyladenylyl‐3′,5′‐2′‐ O ‐methyladenosine ethylphosphotriesters and 2′‐ O ‐methyladenylyl‐3′,5′‐2′‐ O ‐methyladenosinc methyl phosphonates with polyuridylic acid and polythymidylic acid was monitored by UV spectral mediods. Possible steric effects on the stability of the triplex are discussed with the aid of simulated chemical structures.