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Synthesis of Azo‐Sulfa Drugs Based on 2‐Pyridinone and 2‐Pyridinethione
Author(s) -
Abdel Hafez Ali A.,
Awad Ibrahim M. A.,
Ahmed Ragaa A.
Publication year - 1993
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199300043
Subject(s) - chemistry , chelation , antifungal , copper , medicinal chemistry , mercury (programming language) , organic chemistry , dermatology , medicine , computer science , programming language
Abstract Some new azo sulfa drugs 3‐cyano‐4,6‐diphenyl‐1‐[4‐( N ‐substituted)sulfamyl]phenylazo‐2‐pyridinone dyes (1‐6) and 3‐cyano‐4,6‐diphenyl‐1‐[4‐( N ‐substituted)sulfamyl]phenylazo‐2‐pyridinethione dyes (1′‐6′) were synthesized by coupling of 4‐( N ‐substituted)sulfamylbenzene diazonium salts with 3‐cyano‐4,6‐diphenyl‐2‐pyridinone and/or with 3‐cyano‐4,6‐diphenyl‐2‐pyridin‐ethione. The corresponding iron (1a‐6a, 1′a‐6′a), copper (1b‐6b, 1′b‐6′b) and mercury (1c‐6c, 1′c‐6′c) chelates wvere also prepared. All synthesized compounds were screened in vitro for antibacterial and antifungal activities.