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Dibenzo[b,e][1,4]diazepin‐1‐Ones, Synthesis and Derivatization
Author(s) -
Rashed N.,
Sayed M.,
El Ashry E. S. H.
Publication year - 1993
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199300027
Subject(s) - chemistry , nitrobenzene , derivatization , tricyclic , acetylation , medicinal chemistry , organic chemistry , stereochemistry , high performance liquid chromatography , biochemistry , gene , catalysis
Several linearly fused tricyclic 6,7,6‐systems were prepared. Reaction of 1,2‐diamino‐4‐nitrobenzene with 5,5‐dimethylcyclohexan‐1,3‐dione gave 3‐(2‐amino‐5‐nitroaniIino)‐5,5‐dimethylcyclohex‐2‐en‐1‐one (8) . Reaction of 8 and its analogue 6 with various aldehydes gave 2,3,4 ) 5,10,11‐hexahydro‐3,3‐dimethyl‐11‐substituted‐1 H ‐dibenzo[b,e][1,4]diazepin‐1‐ones 9 and 10 . Acetylation of 9 and 10 gave the corresponding N ‐acetyl derivatives. Spectral data of the products are discussed.