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Heterocyclic Synthesis with Enamines: Convenient Syntheses of Polyfunctionally Substituted Pyrazole, Pyridine, Pyrimidine and Pyrazolo[3,4‐ d ]pyrimrdine Derivatives
Author(s) -
Mohareb Rafat Milad,
Sherif Sherif Mourad,
Zohdi Hussein Fouad
Publication year - 1993
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199300026
Subject(s) - chemistry , pyrimidine , thiourea , pyrazole , pyridine , reagent , nitrile , methylene , ketone , ring (chemistry) , phenyl isothiocyanate , isothiocyanate , organic chemistry , combinatorial chemistry , medicinal chemistry , stereochemistry
Facile syntheses of pyrazole, pyridine, pyrimidine and pyrazolo[3,4‐ d ]pyrimidine derivatives have been achieved by the reaction of β‐enamino nitrile 2a with hydrazines, phenyl isothiocyanate, thiourea and active methylene reagents. The β‐enamino ketone 2e with the same reagents affords 3,5‐dimethyl heterocyclic ring systems.