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Synthesis of 4‐Arylpyridines Containing Electron‐Withdrawing Groups on the Benzene Ring
Author(s) -
Shiao MinJen,
Liu KangHsiuan,
Wang JyShih
Publication year - 1993
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199300025
Subject(s) - chemistry , benzene , ring (chemistry) , toluene , chloranil , trifluoromethyl , nitrile , medicinal chemistry , pyridinium , polar effect , aryl , zinc , fluoride , polymer chemistry , organic chemistry , inorganic chemistry , alkyl
Abstract 4‐Arylpyridines 5 that contain electron‐withdrawing groups such as nitrile, methyl ester, fluoride, and trifluoromethyl on the benzene ring were synthesized in moderate yields (29‐63%) by reaction of mixed copper, zinc aryl organometallics 1 with various 1‐(ethoxycarbonyi)pyridinium chlorides 2 followed by o‐ chloranil oxidization under reflux in toluene.