Synthesis of 4‐Arylpyridines Containing Electron‐Withdrawing Groups on the Benzene Ring | Zendy

Shiao MinJen | Zendy; Liu KangHsiuan | Zendy; Wang JyShih | Zendy

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Synthesis of 4‐Arylpyridines Containing Electron‐Withdrawing Groups on the Benzene Ring

Author(s) -

Shiao MinJen,

Liu KangHsiuan,

Wang JyShih

Publication year - 1993

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.199300025

Subject(s) - chemistry , benzene , ring (chemistry) , toluene , chloranil , trifluoromethyl , nitrile , medicinal chemistry , pyridinium , polar effect , aryl , zinc , fluoride , polymer chemistry , organic chemistry , inorganic chemistry , alkyl

4‐Arylpyridines 5 that contain electron‐withdrawing groups such as nitrile, methyl ester, fluoride, and trifluoromethyl on the benzene ring were synthesized in moderate yields (29‐63%) by reaction of mixed copper, zinc aryl organometallics 1 with various 1‐(ethoxycarbonyi)pyridinium chlorides 2 followed by o‐ chloranil oxidization under reflux in toluene.

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