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Enantioselective Synthesis of N ‐[(S)‐Ethoxycarbonyl‐3‐phenylpropyl]‐L‐alanyl‐L‐proline from Chiral Synthon Prepared Enzymatically; A Practical Method for Large‐Scale Synthesis
Author(s) -
Tseng TsungChin,
Duo TsaiHui,
Wang YiFong
Publication year - 1991
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199100081
Subject(s) - chemistry , synthon , enantioselective synthesis , stereospecificity , stereochemistry , enalapril , acetylation , proline , combinatorial chemistry , organic chemistry , angiotensin converting enzyme , catalysis , biochemistry , amino acid , medicine , radiology , gene , blood pressure
Efficient procedures have been developed for the stereospecific synthesis of Angiotensin‐converting enzyme inhibitor, Enalapril. The starting material, ( R )‐2‐hydroxy‐4‐phenylbutyronitrile, is prepared from lipase‐catalyzed acetylation. This process is useful for multigram‐scale synthesis.