Enantioselective Synthesis of  N ‐[(S)‐Ethoxycarbonyl‐3‐phenylpropyl]‐L‐alanyl‐L‐proline from Chiral Synthon Prepared Enzymatically; A Practical Method for Large‐Scale Synthesis | Zendy

Tseng TsungChin | Zendy; Duo TsaiHui | Zendy; Wang YiFong | Zendy

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Enantioselective Synthesis of N ‐[(S)‐Ethoxycarbonyl‐3‐phenylpropyl]‐L‐alanyl‐L‐proline from Chiral Synthon Prepared Enzymatically; A Practical Method for Large‐Scale Synthesis

Author(s) -

Tseng TsungChin,

Duo TsaiHui,

Wang YiFong

Publication year - 1991

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.199100081

Subject(s) - chemistry , synthon , enantioselective synthesis , stereospecificity , stereochemistry , enalapril , acetylation , proline , combinatorial chemistry , organic chemistry , angiotensin converting enzyme , catalysis , biochemistry , amino acid , medicine , radiology , gene , blood pressure

Efficient procedures have been developed for the stereospecific synthesis of Angiotensin‐converting enzyme inhibitor, Enalapril. The starting material, ( R )‐2‐hydroxy‐4‐phenylbutyronitrile, is prepared from lipase‐catalyzed acetylation. This process is useful for multigram‐scale synthesis.

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