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Transformation of “Masked” 1,3‐Diols of Protected α‐D‐Erythro‐Hexopyranoside into Acyclic Forms. Chirons for Amphotericin B and Tetrin A
Author(s) -
Liang David WoeiMing,
FraserReid Bert
Publication year - 1991
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199100031
Subject(s) - chemistry , diastereomer , transformation (genetics) , amphotericin b , aldehyde , iodide , chloride , stereochemistry , medicinal chemistry , organic chemistry , antifungal , microbiology and biotechnology , biochemistry , catalysis , gene , biology
Methyl 3‐ O ‐benzyl‐2,4‐dideoxy‐D‐ erythro ‐hexopyranoside 1a, a chiron for the C1‐C6 segment of amphotericin B and tetrin A, has been successfully converted to aldehyde 3; chloride 5d and iodide 7c in high yields, which are the acyclic forms of 1,3‐diols.