Synthesis of Some New Pyrazolo[3,4‐ b ]Pyridlne and Pyrazolo[3,4‐ d ]Pyrimidine Derivatives 1 | Zendy

Younes Mansour I. | Zendy; Abbas Hessan H. | Zendy; Metwally Saoud A.M. | Zendy

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Synthesis of Some New Pyrazolo[3,4‐ b ]Pyridlne and Pyrazolo[3,4‐ d ]Pyrimidine Derivatives 1

Author(s) -

Younes Mansour I.,

Abbas Hessan H.,

Metwally Saoud A.M.

Publication year - 1990

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.199000084

Subject(s) - malononitrile , chemistry , pyrimidine , pyridine , ethyl cyanoacetate , pyrazole , medicinal chemistry , stereochemistry , organic chemistry , catalysis

Several pyrazolo[3,4‐ b ]pyridine (3,4) and pyrazolo‐[3,4‐ d ]pyrimidine (5‐13) derivatives were prepared using 5‐amino‐l‐(5‐ethyl‐5 H ‐1,2,4‐triazino[5,6‐ b ]‐indol‐3‐yl)‐l H ‐pyrazole‐4‐carbonitrile (2) . The pyridine derivatives 3 and 4 were obtained by reaction of 2 with malononitrile and ethyl cyanoacetate, respectively, while pyrimidine analogs 5‐13 were synthesized cither by a one‐step or multi‐step sequence.

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