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Synthesis of Some New Pyrazolo[3,4‐ b ]Pyridlne and Pyrazolo[3,4‐ d ]Pyrimidine Derivatives 1
Author(s) -
Younes Mansour I.,
Abbas Hessan H.,
Metwally Saoud A.M.
Publication year - 1990
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199000084
Subject(s) - malononitrile , chemistry , pyrimidine , pyridine , ethyl cyanoacetate , pyrazole , medicinal chemistry , stereochemistry , organic chemistry , catalysis
Several pyrazolo[3,4‐ b ]pyridine (3,4) and pyrazolo‐[3,4‐ d ]pyrimidine (5‐13) derivatives were prepared using 5‐amino‐l‐(5‐ethyl‐5 H ‐1,2,4‐triazino[5,6‐ b ]‐indol‐3‐yl)‐l H ‐pyrazole‐4‐carbonitrile (2) . The pyridine derivatives 3 and 4 were obtained by reaction of 2 with malononitrile and ethyl cyanoacetate, respectively, while pyrimidine analogs 5‐13 were synthesized cither by a one‐step or multi‐step sequence.