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Some Novel Thiazoline and Thiazolidinone Derivatives Surmounted on Substituted Pyrazole Moieties as Potential Antipyretic Agents
Author(s) -
Farghaly A.M.,
Chaaban I.,
ElKhawass S.M.,
Fahmy S. M.
Publication year - 1990
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199000069
Subject(s) - chemistry , thiazoline , phenacyl bromide , pyrazole , antipyretic , phenacyl , bromide , semicarbazone , medicinal chemistry , organic chemistry , stereochemistry , analgesic , pharmacology , medicine
Six novel series of substituted thiazoline (V, VI, VII and VIII) and thiazolidinone derivatives (IX and X) resulting from 2,3‐dihydro‐1, 5‐dimethyl‐3‐oxo‐2‐phenyl‐1H‐pyrazole‐4‐carbaldehyde (I) and 1‐phenyl‐3‐ p ‐tolyl‐1H‐pyrazolc‐4‐carbaldehyde (II) were synthesized. The course of this synthesis included the preparation of two new scries of disubstituted thiosemicarbazone precursors (III and IV) which were cyclized with phenacyl bromide, ethyl 2‐chloroacetoacetate as well as ethyl bromoacetatc to afford the target thiazolines and thiazolidinoncs. The antipyretic activity of some representative compounds was performed.