An Efficient Synthesis of 8‐Amino‐9‐Benzylguanine | Zendy

Chern JiWang | Zendy; Kuo JihAn | Zendy; Lu GuanYu | Zendy

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An Efficient Synthesis of 8‐Amino‐9‐Benzylguanine

Author(s) -

Chern JiWang,

Kuo JihAn,

Lu GuanYu

Publication year - 1989

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.198900081

Subject(s) - chemistry , isothiocyanate , yield (engineering) , sodium hydroxide , phenyl isothiocyanate , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , materials science , metallurgy

The reaction of 2,5‐diamino‐4‐benzylamino‐pyrimidin‐6(III)‐one (6) with benzoyl isothiocyanate furnished 2‐amino‐4‐benzylamino‐5‐[1‐(3‐benzoylthioureido)]‐pyrimidin‐6(1H)‐one (7) in good yield. The title compound I was synthesized from compound 7 via a cyclodesulfurative reaction with DCC in DMF at 80°C directly to form 8‐benzoylamino‐9‐benzylguanine (9) which was subsequently treated with 1 N sodium hydroxide.

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