Premium
An Efficient Synthesis of 8‐Amino‐9‐Benzylguanine
Author(s) -
Chern JiWang,
Kuo JihAn,
Lu GuanYu
Publication year - 1989
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.198900081
Subject(s) - chemistry , isothiocyanate , yield (engineering) , sodium hydroxide , phenyl isothiocyanate , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , materials science , metallurgy
The reaction of 2,5‐diamino‐4‐benzylamino‐pyrimidin‐6(III)‐one (6) with benzoyl isothiocyanate furnished 2‐amino‐4‐benzylamino‐5‐[1‐(3‐benzoylthioureido)]‐pyrimidin‐6(1H)‐one (7) in good yield. The title compound I was synthesized from compound 7 via a cyclodesulfurative reaction with DCC in DMF at 80°C directly to form 8‐benzoylamino‐9‐benzylguanine (9) which was subsequently treated with 1 N sodium hydroxide.