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Syntheses of 2,4′‐and 3,4′‐Bipyridines Via Lithium Halogen Exchange of Bromopyridines and Addition to N ‐Ethoxycarbonylpyridinium Chloride in the Presence of Cul
Author(s) -
Shiao MinJen,
Tarng KaiYih,
Shyu LiMing
Publication year - 1989
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.198900080
Subject(s) - chemistry , halogen , yield (engineering) , reagent , lithium (medication) , chloride , lithium chloride , medicinal chemistry , inorganic chemistry , organic chemistry , metallurgy , medicine , alkyl , materials science , endocrinology
2,4′‐Bipyridines 4a, 4c, 4d and 3,4′‐bipyridines 4b, 4e, 4f, 4g, 4h are obtained in modest yield by the addition of organocuprate reagents derived from bromopyridines 2a‐h to N‐ethoxycarbonylpyridinium chloride 1 followed by air oxidation.