Premium
Encapsulation and Prolonged Release Behaviour of W/O/W Type Multiple Emulsions
Author(s) -
Lin TsuiHua,
Lin ShanYang
Publication year - 1988
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.198800070
Subject(s) - chemistry , poloxamer , emulsion , chromatography , aqueous solution , dissolution , aqueous two phase system , chemical engineering , nuclear chemistry , copolymer , organic chemistry , engineering , polymer
W/O/W type multiple emulsions were prepared by two step emulsification procedures using an oily lymphographic agent, lipiodol, as an inner oil phase and Pluronic F‐68 as a hydrophilic emulsifier contained in the outer aqueous phase. Span 80, Pluronic L‐64 and HCO‐60 were used as emulsifiers incorporating them into the inner oil phase. The phase volume of the inner and outer aqueous phases and the yield of the w/o/w type multiple emulsions were studied. The dissolution behaviour of the w/o/w type multiple emulsions were determined by a dialysis method employing cellulose tubing. The effect of emulsifier type and the amount of HCO‐60 on the stability and prolonged release behavior of the w/o/w type multiple emulsions with or without lecithin, was also examined. The results indicate the HCO‐60 is a better emulsifier than Span 80 or Pluronic L‐64. Its use improves the stability and the prolonged release behavior of w/o/w type multiple emulsions.