A Practical Formal Synthesis of a Physiologically Active Analogue of Platelet Activating Factor | Zendy

Tsai YeunMin | Zendy; Jiang ShuLi | Zendy; Chen HueiJu | Zendy; Chau LeeYoung | Zendy; Lin JinTay | Zendy

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A Practical Formal Synthesis of a Physiologically Active Analogue of Platelet Activating Factor

Author(s) -

Tsai YeunMin,

Jiang ShuLi,

Chen HueiJu,

Chau LeeYoung,

Lin JinTay

Publication year - 1988

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.198800065

Subject(s) - chemistry , yield (engineering) , platelet activating factor , phosphocholine , formal synthesis , platelet , glycerol , combinatorial chemistry , stereochemistry , biochemistry , medicine , membrane , phospholipid , phosphatidylcholine , materials science , metallurgy

A synthesis of phosphocholine 9 was accomplished in 36% yield from isopropylidene glycerol in contrast to 2% yield as reported previously. Since 9 has been converted to platelet activating factor‐analogue 2, this report constitutes a more practical synthesis of 2.

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