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A Practical Formal Synthesis of a Physiologically Active Analogue of Platelet Activating Factor
Author(s) -
Tsai YeunMin,
Jiang ShuLi,
Chen HueiJu,
Chau LeeYoung,
Lin JinTay
Publication year - 1988
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.198800065
Subject(s) - chemistry , yield (engineering) , platelet activating factor , phosphocholine , formal synthesis , platelet , glycerol , combinatorial chemistry , stereochemistry , biochemistry , medicine , membrane , phospholipid , phosphatidylcholine , materials science , metallurgy
A synthesis of phosphocholine 9 was accomplished in 36% yield from isopropylidene glycerol in contrast to 2% yield as reported previously. Since 9 has been converted to platelet activating factor‐analogue 2, this report constitutes a more practical synthesis of 2.