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Synthesis of Certain S‐Triazole and s‐Triazolo[3,4‐B] 1,3,4‐Thiadiazole Derivatives of Expected Pharmacological Activity
Author(s) -
Eisa H. M.,
ElEmam A. A.,
Moustafa M. A.,
ElKerdawy M. M.
Publication year - 1988
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.198800058
Subject(s) - chemistry , thiadiazoles , acetic anhydride , ring (chemistry) , alkyl , triazole , mass spectrum , medicinal chemistry , 1,2,4 triazole , derivative (finance) , organic chemistry , catalysis , ion , financial economics , economics
Reaction of the newly prepared 3‐(2‐thienyl)‐4‐amino‐s‐triazole‐5‐thione (I) with different alkyl kalides and aromatic aldehydes afforded the corresponding thioethers and arylidene derivatives (II and III), respectively. Attempt ring closure of (I) with acetic anhydride produced the unexpected triacetyl derivative (IV). The synthesis of certain 3‐(2‐thienyl)‐6‐substituted‐s‐triazolo[3,4‐b] 1,3,4‐thiadiazoles (V and VII) was described. IR, NMR and mass spectral analyses of the prepared compounds were discussed.