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Syntheses of Bissydnone Derivatives and Studies of Their Biological Activities
Author(s) -
Tien HsienJu,
Lai LongLi,
Lee YaoKueng,
Chuang ChePing,
Yeh MouYung,
Wu TianShung
Publication year - 1988
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.198800035
Subject(s) - chemistry , paraformaldehyde , potassium cyanide , diamine , ether , sodium bisulfite , medicinal chemistry , potassium , cyanide , potassium ferricyanide , nuclear chemistry , organic chemistry
A new method to prepare 3,3′‐ethylenebissydnone (40%), 3,3′‐tetramethylenebissydnone (37%) and 3,3′‐hexamethylenebissydnone (43%) from the corresponding alkylene diamine with paraformaldehyde and potassium cyanide were investigated. Some new bissydone: −3,3′‐trimethylenebissydnone (6%), 3,3′‐(4,4′‐diphenyl)bissydnonylmethane (9%) and 3,3′‐(4,4′‐diphenyi)bissydnonyl ether (28%) were synthesized from the corresponding diamine, paraformaldehyde, sodium bisulfite and potassium cyanide. Biological test of 3,3′‐(4,4′‐diphenyl)bissydnonylmethane shows significant response for coronary dilgtion test, inhibition of collagen induced platelet aggregation and moderate carditropic response. 3,3′‐(4,4′‐Diphenyl)bissydnonyl ether also shows inhibition of collagen induced platelet aggregation and moderate carditropic response.