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Solution Behavior of Aromatic Dipeptides. II. The Mechanistic Aspect of the Coupling Reaction and Conformation Study of Diastereomers
Author(s) -
Chu YenHo,
Chen ShuiTein,
Wang KungTsung
Publication year - 1988
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.198800031
Subject(s) - chemistry , diastereomer , racemization , stereochemistry , coupling (piping) , coupling reaction , computational chemistry , organic chemistry , catalysis , mechanical engineering , engineering
A systematic racemization study of the coupling of Z‐Phe with Phe‐OBzl has been carried in order to determine the optimal conditions. It is found that the L,D diastereomer is the favored product in the coupling of Z‐L‐Phe with D,L‐Phe‐OBzl. A possible mechanism is proposed and elucidated by NMR studies.