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Deprotonation/Alkylation Reactions of Sulfolenes
Author(s) -
Chou TaShue,
Yu ChinFen
Publication year - 1987
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.198700032
Subject(s) - deprotonation , chemistry , alkylation , methyl iodide , iodide , organic chemistry , medicinal chemistry , catalysis , ion
Deprotonation/methylation reactions have been carried out on a series of substituted 2‐sulfolenes and 3‐sulfolenes. For 2‐sulfolenes, both allylic and vinylic deprotonation reactions occur to give, after treatment with methyl iodide, 2‐methylated 3‐sulfolenes and 2‐methylated 2‐sulfolenes. These products are useful intermediates because substituted 3‐sulfolenes are precursors to substituted butadienes and 2‐alkylated 2‐sulfolenes are precursors to β‐functionalized trans olefins.