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A Facile Synthesis of 3,4‐Diamino‐2,5‐Diacylthieno[2,3‐b]Thiophenes from Disodium(Dimercaptomethylene)Malononitrile and α‐Halo Ketones
Author(s) -
Fuchigami Toshio,
Kandeel Zaghloul ElShahat,
aka Tsutomu,
Tien HsienJu
Publication year - 1986
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.198600032
Subject(s) - malononitrile , sydnone , chemistry , derivative (finance) , medicinal chemistry , halo , organic chemistry , ring (chemistry) , catalysis , financial economics , economics , physics , quantum mechanics , galaxy
Various kinds of α‐halo ketones readily reacted with disodium (dimercaptomethylene)malononitrile to give the corresponding 34‐diamino‐2,5‐diacylthieno‐[2,3‐b]thiophenes in good to excellent yields. The reaction was successfully extended to the synthesis of a thienothiophene derivative having two sydnone rings by using the 4‐(bromoacetyl)sydnone.