Synthesis of ( S )‐Propranolol by Chemicoenzymatic Approach | Zendy

Wang YiFong | Zendy; Kou HwangShang | Zendy; Lee Becky | Zendy; Hwang LihYueh | Zendy

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Synthesis of ( S )‐Propranolol by Chemicoenzymatic Approach

Author(s) -

Wang YiFong,

Kou HwangShang,

Lee Becky,

Hwang LihYueh

Publication year - 1986

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.198600025

Subject(s) - chemistry , propranolol , hydrolysis , optically active , medicinal chemistry , propanol , absolute configuration , blocking (statistics) , stereochemistry , organic chemistry , medicine , statistics , mathematics , methanol

( S )‐Propranolol, [1‐isopropylamino‐3‐(1‐naphthoxy)‐2‐propanol], which possesses important β‐adrenergic blocking activity, has been synthesized by a chemicoenzymatic approach. The 2 S ‐absolute configuration was created by the enzyme‐mediated asymmetric hydrolysis of the (±)‐2‐acetoxy‐1‐chloro‐3‐(1‐naphthoxy)‐2‐naphthoxy)‐2‐propanol. The enzymatically produced chiral intermediate was then chemically converted to optically pure ( S )‐propranolol.

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