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Synthesis of 5‐(3‐ Tert ‐Butylamino‐2‐Hydroxy) Propoxy‐3,4‐Dihydrocarbostyril
Author(s) -
Chen LingChing,
Lin JenHom,
Wu ShihnSheng
Publication year - 1984
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.198400060
Subject(s) - chemistry , yield (engineering) , catalytic hydrogenation , catalysis , wittig reaction , medicinal chemistry , organic chemistry , materials science , metallurgy
5‐(3‐ tert ‐Butylamino‐2‐hydroxy) propoxy‐3, 4‐dihydrocarbostyril ( 1 , carteolol) was prepared by an acid‐catalyzed cyclization of the N ‐pivaloylamino‐ester ( 5 ), which was obtained by using organolithiation of m ‐pivaloylanisidine, followed by Wittig and catalytic hydrogenation reactions. The total yield of 1 obtained from m ‐anisidine ( 2 ) is 21%.