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Syntheses of 1‐Azaazulan‐2‐One Analogs of Adrenergic Agents
Author(s) -
Wu ChiPhi,
Jiang George J.,
Hung YaYung,
Yang PawWang
Publication year - 1984
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.198400052
Subject(s) - chemistry , sodium borohydride , amine gas treating , adrenergic , chloride , sodium , organic chemistry , catalysis , biochemistry , receptor
The Friedel‐Crafts reaction of 1‐azaazulan‐2‐ones with α‐haloacid chloride in the presence of aluminum trichloride gives the corresponding α‐haloacyl derivatives. Treatment of these reaction products first with various secondary amines and then with sodium borohydride gives new adrenergic active amine derivatives.