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Preparation of Enamines Catalyzed by Lewis Acids in the Presence of Solid Supports
Author(s) -
Chou ShangShing P.,
Chu ChengWu
Publication year - 1984
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.198400050
Subject(s) - chemistry , lewis acids and bases , regioselectivity , solid acid , yield (engineering) , catalysis , lewis acid catalysis , organic chemistry , solid state , combinatorial chemistry , metallurgy , materials science
A simple and effective preparation of enamines from bulky ketones and secondary amines has been achieved with the aid of Lewis acid on various solid supports. The optimized yields were higher than those obtained without the solid support. Factors affecting the yield and regioselectivity of these reactions were also studied. Evidence showed that the reaction proceeded simultaneously in solution and on the solid support.