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A NMR Study of Magnetic Nonequivalence of Methylene Protons in Some 1,1,2‐Trisubstituted Ethanes of the Type XCH 2 CHXY
Author(s) -
Lin Shin,
Lin WeiChuwan
Publication year - 1981
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.198100033
Subject(s) - chemistry , methylene , benzene , conformational isomerism , asymmetry , computational chemistry , medicinal chemistry , organic chemistry , stereochemistry , molecule , physics , quantum mechanics
Magnetic nonequivalence of methylene protons in some 1,1,2‐trisubstituted ethanes of the type XCH 2 CHXY was studied in the medium of various solvents over the temperature range of 0–95° C . Asymmetry effect and rotamer populations have been considered to be two major contributions to magnetic nonequivalence of methylene protons in the title compounds. A graphic method has been proposed to determine the asymmetry effect for methyl 2,3‐dibromopropionate, ethyl 2,3‐dibromopropionate, methyl 2,3‐dichloropropionate, and (1,2‐dibromoethyl) benzene in various solvents.